Synthetic target of lobular breast cancer - Research • Breast Cancer Foundation NZ

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Synthetic target of lobular breast cancer

Professor Parry Guilford - University of Otago
Professor Parry Guilford - University of Otago
February 2014
Research Grant

What is the problem and who is affected?

For a cancer to occur and develop, tumour suppressor genes must be inactivated. If it was possible to prevent this from happening, then cancer tumours wouldn't be able to grow. Unfortunately, when this happens the tumour suppressor protein is lost from the cell, so it can't be targeted by conventional therapy.

What is this research hoping to achieve?

Guilford and his team are convinced that the loss of tumour suppressor gene CDH1, creates vulnerabilities in the cancer cell that can be targeted by drugs. They aim to study these vulnerabilities and develop new breast cancer treatments which are able to target them.