THYmine2 - Clinical trial • Breast Cancer Foundation NZ

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THYmine2

Advanced Breast Cancer clinical trials for Other

Recruiting
Updated: May 12, 2020

THYmine2 is an observational study to assess whether the thymine loading test can prospectively categorize patients who cannot tolerate 5-FU treatment (e.g. FOLFOX, CapeOx, FLOX). This treatment is commonly used in breast cancer treatment. Reactions occur in approximately 10% of patients and can result in life-threatening events.

Despite extensive research, it is still difficult to determine who is at risk of life-threatening toxicity related to 5-FU. This study aims to examine whether the ratio of thymine to its metabolite in urine can discriminate between patients who tolerate 5-FU and those who experience severe 5-FU related toxicity. If successful then it could be a simple and inexpensive way to identify susceptible patients before they start treatment and allow for dose adjustments or alternative treatment.

Eligibility criteria:

  • Age >18 years.
  • To receive 5-FU or capecitabine (GI) or capecitabine (mBC) as part of standard care for histologically or cytologically confirmed gastrointestinal (GI) cancer or metastatic breast cancer (mBC); or
  • To receive capecitabine as part of standard care for residual disease present at surgery following neoadjuvant chemotherapy for breast cancer
  • Able to provide written informed consent

For full trial information

New Zealand

Auckland City Hospital
Canopy Cancer Care (Auckland)
Tauranga Hospital
Christchurch Hospital
Dunedin Hospital

Contact:

Kelly Fredell

If you think you might be a candidate for this trial, use the contact details supplied, or talk to your doctor.

Want to access a trial that's not in your area? It's not always possible, but if you're interested, email us at intouch@bcf.org.nz

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