Clinical Trials

The purpose of this study is to assess the efficacy and safety of pembrolizumab (Keytruda) versus placebo in combination with neoadjuvant (pre-surgery) chemotherapy and adjuvant (post-surgery) endocrine therapy in the treatment of adults who have high-risk early-stage estrogen receptor-positive, human epidermal growth factor receptor 2-negative (ER+/HER2-) breast cancer.
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This study looks at anti-HER2 therapy plus endocrine therapy with or without palbociclib in patients with hormone receptor-positive HER2+ metastatic breast cancer. This study aims to extend the time before the disease progresses.
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The aim of the POSNOC trial is to find out if further axillary treatment is of benefit in women with macrometastases found in one or two lymph nodes.
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A randomised clinical trial of adjuvant radiation therapy versus observation following breast conserving surgery and endocrine therapy in patients with molecularly characterised luminal A low risk early breast cancer.
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This phase 2 clinical trial is looking into lymph node grafting for upper limb lymphoedema following breast cancer treatment.
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The New Zealand Familial Breast Cancer Study commenced in 2013 with the key goal of better-understanding DNA sequence changes in genes that alter the risk of developing breast cancer 
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The PantoCIN trial will test the ability of a cheap, widely available drug to prevent two of chemotherapy’s most unpleasant side-effects: delayed nausea and vomiting.
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A study assessing the safety and effectiveness of Q-122 for treating hot flushes, in women who have, or have had, breast cancer.
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THYmine2 is an observational study to assess whether the thymine loading test can prospectively categorize patients who cannot tolerate 5-FU treatment (e.g. FOLFOX, CapeOx, FLOX). This treatment is commonly used in breast cancer treatment. Reactions occur in approximately 10% of patients and can result in life-threatening events.
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This is a proof-of-concept pilot study to determine if short-term treatment with denosumab (trade names Prolia and Xgeva) is a feasible chemoprevention option against breast cancer for BRCA1 and BRCA2 mutation carriers, as well as high risk, non-BRCA carriers.
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A phase II study evaluating the efficacy and safety of Ipilimumab and Nivolumab with neoadjuvant weekly paclitaxel after anthracycline-based chemotherapy in high-risk primary triple negative breast cancer, followed by definitive surgery and one-year total duration of Nivolumab.
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You can join this phase 3 study if you've been diagnosed with early invasive breast cancer and you have had or will have, surgery for this, and you also plan to have chemotherapy as part of your anti-cancer treatment.
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This is a study to evaluate safety, pharmacokinetics, pharmacodynamics, and preliminary antitumor activity of avelumab (MSB0010718C) in combination with other cancer immunotherapies in patients with locally advanced or metastatic solid tumors.
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Lifepool is a research resource for study into breast cancer and women's health. It aims to recruit 100,000 Australian women. This will establish one of the largest cohorts in the world, providing research tools to answer critical questions about breast cancer. Lifepool aims to gather information on health and lifestyle, mammogram data and asks permission to track the health of each participant through linkage with other health databases.
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A phase 2 study of local therapy (stereotactic radiosurgery and/or surgery) for treatment of up to five brain metastases from HER2 positive breast cancer.
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This study aims to find out if women with locally advanced breast cancer can have breast conserving surgery instead of mastectomy with a low chance of the cancer returning.
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An open-label, randomized, window of opportunity study between diagnosis and definite surgery, to assess the effect of antiestrogen therapies, alone and in combination with microionized progesterone (prometrium) in patients with newly diagnosed ER+PR+ breast cancer.
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A study to evaluate the safety and tolerability of immunotherapy combinations in participants with advanced malignancies
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This is an open-label, multicenter, global phase 2 basket study of entrectinib (RXDX-101) for the treatment of patients with solid tumors that harbor an NTRK1/2/3 or ROS1 gene fusion.
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This is phase 2 study of pre-operative endocrine therapy with and without prometrium in postmenopausal women with early stage breast hormone receptor positive, human epidermal receptor 2 negative breast cancer.
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The purpose of this study is to determine if breast cancer genetic material (known as circulating tumour DNA (ctDNA) can be detected in the bloodstream. It is hoped that this research will demonstrate the utility of this circulating material as an early marker of residual or recurrent breast cancer activity after treatment
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