Breast Cancer Foundation NZ
CAMBRIA-2
Early Breast Cancer clinical trials for ER+
CAMBRIA-2 is a phase III study investigating a new endocrine treatment, camizestrant, which is a ‘selective oestrogen receptor degrader’ (SERD) for patients with ER+/HER2- early breast cancer with intermediate-high or high risk for disease recurrence .
The study aims to find out if giving a SERD is better at reducing the chance of cancer from coming back compared with the usual endocrine treatments such as letrozole (Letrol), anastrozole (Anatrole or Arimidex), exemestane (Aromasin) or tamoxifen (Sandoz or Genox). The research will also find out more about the side effects, safety and effectiveness of the SERD.
Who is it for?
- Women and Men aged ≥18 years
- ER+/HER2- early-stage invasive breast cancer who have completed surgery within the past 12 months
Even if you meet the above criteria, there are exclusion criteria which might mean that you will not be able to participate - check with your study centre to see whether this study is right for you.
What's involved?
If you join this study you will be put into one of two study groups:
- Group A (Usual Treatment): Participants will receive standard endocrine (hormone) treatment.
- Group B (Research Treatment): Participants will take 2 SERD tablets once per day.
Participants may also take a treatment called a CDK4/6 inhibitor that is now commonly given with endocrine treatment to patients with a high risk of cancer recurrence.
Participants will take study treatment for up to 7 years, and will continue follow up once or twice a year until 10 years after the last person joins the study. Study visits will be at screening, Month 1, Month 4, Month 7, then every 6 months to 7 years. Follow up visits will be every 12 months. The total duration of the study will be approximately 14 years.
CAMBRIA-2 will recruit 5500 patients at approximately 700 sites across 40 countries over 3 and a half years. Twenty-five sites in Australia and three in New Zealand will be recruiting patients.
More information can be found here
New Zealand
Waikato
Palmerston North
Australia
NSW
QLD
VIC
WA
If you think you might be a candidate for this trial, use the contact details supplied, or talk to your doctor.
Want to access a trial that's not in your area? It's not always possible, but if you're interested, email us at intouch@bcf.org.nz
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Are we out of date? If you have updated or new information about a trial, we’d be grateful if you’d share it with us – email your update to intouch@bcf.org.nz
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