EXPERT - Clinical trial • Breast Cancer Foundation NZ

EXPERT

Early Breast Cancer clinical trials for ER+

Recruiting
Updated: January 14, 2020

A randomised clinical trial of adjuvant radiation therapy versus observation following breast conserving surgery and endocrine therapy in patients with molecularly characterised luminal A low risk early breast cancer.

Radiotherapy after breast-conserving surgery to improve local control and survival is the current standard of care for patients with early breast cancer. However, breast cancer is a heterogeneous disease, and the absolute benefit of radiotherapy in individual patients varies substantially. Thus, a pressing priority in contemporary breast cancer management is to tailor radiotherapy utilisation to the individuals recurrence risks by identifying patients who are unlikely to benefit from radiotherapy, thereby avoiding the morbidity and costs of over-treatment.

EXPERT presents a unique opportunity of clinical and public health importance to optimise personalised local therapy for early breast cancer through precise, individualised quantification of local recurrence risk to identify low-risk patients for whom RT after breast-conserving surgery may be safely omitted.

Eligibility criteria:

  • Female patient aged 50 years or more, of any menopausal status
  • Confirmed invasive breast tumour
    • Grade 1 or 2
    • 2cm or less
    • ER and PR positive in 10% or more of tumour cells
    • HER2-negative
    • Luminal A subtype
  • No evidence of metastasis
  • ECOG performance status of 0-2

Recruitment will take place in Christchurch, Palmerston North, Hamilton and Wellington, as well as various areas in Australia.

For full trial information

New Zealand

Waikato Hospital
Palmerston North Hospital
Wellington Hospital
Christchurch Hospital

Contact:

Waikato Hospital: Ian Campbell
Palmerston North Hospital: Claire Hardie
Wellington Hospital: Anna Nicholson
Christchurch Hospital: Melissa James

If you think you might be a candidate for this trial, use the contact details supplied, or talk to your doctor.

Want to access a trial that's not in your area? It's not always possible, but if you're interested, email us at intouch@bcf.org.nz

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