Breast Cancer Foundation NZ
THYmine2
Advanced Breast Cancer clinical trials for Other
THYmine2 is an observational study to assess whether the thymine loading test can prospectively categorize patients who cannot tolerate 5-FU treatment (e.g. FOLFOX, CapeOx, FLOX). This treatment is commonly used in breast cancer treatment. Reactions occur in approximately 10% of patients and can result in life-threatening events.
Despite extensive research, it is still difficult to determine who is at risk of life-threatening toxicity related to 5-FU. This study aims to examine whether the ratio of thymine to its metabolite in urine can discriminate between patients who tolerate 5-FU and those who experience severe 5-FU related toxicity. If successful then it could be a simple and inexpensive way to identify susceptible patients before they start treatment and allow for dose adjustments or alternative treatment.
Eligibility criteria:
- Age >18 years.
- To receive 5-FU or capecitabine (GI) or capecitabine (mBC) as part of standard care for histologically or cytologically confirmed gastrointestinal (GI) cancer or metastatic breast cancer (mBC); or
- To receive capecitabine as part of standard care for residual disease present at surgery following neoadjuvant chemotherapy for breast cancer
- Able to provide written informed consent
New Zealand
Canopy Cancer Care (Auckland)
Christchurch Hospital
Dunedin Hospital
Tauranga Hospital
Contact:
Kelly FredellIf you think you might be a candidate for this trial, use the contact details supplied, or talk to your doctor.
Want to access a trial that's not in your area? It's not always possible, but if you're interested, email us at intouch@bcf.org.nz
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