PALVEN - Clinical trial • Breast Cancer Foundation NZ

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Updated: February 3, 2020

This study is investigating the combination of palbociclib, letrozole and venetoclax in ER and BCL-2 positive locally advanced or metastatic breast cancer.

It is hypothesised that venetoclax may increase the actions of palbociclib and letrozole in these patient groups. The primary objective of the study is to determine the maximum tolerated dose of the combination treatment, which can be used in subsequent studies. The study will also investigate disease response and survival.

Participants will receive palbociclib (daily, on days 1-21 of each 28 day cycle), letrozole (daily, on days 1-28 of each 28 day cycle) and venetoclax (daily, on days 1-21 of each 28 day cycle) until the last patient has completed 18 months treatment on the study.

Full trial information


Austin Health, Melbourne (not yet recruiting)
Peter MacCallum Cancer Centre, Melbourne
Royal Melbourne Hospital, Melbourne


Geoffrey Lindeman

If you think you might be a candidate for this trial, use the contact details supplied, or talk to your doctor.

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