Standard treatment for early breast cancer that has spread to one or two lymph nodes includes further treatment to the armpit. Research suggests that it may be possible to avoid the removal of all axillary nodes. Patients may be spared the potential side effects of having extra treatment to the axilla including lymphoedema.
The study will compare adjuvant therapy alone with adjuvant therapy plus axillary treatment (axillary node clearance (ANC) or axillary radiotherapy (ART)).
Participants will be followed up for five years.
All participants will receive adjuvant systemic therapy (chemotherapy and/or endocrine therapy). All participants may receive breast/chest wall radiotherapy. Axillary and supraclavicular fossa radiotherapy is not allowed when randomised to adjuvant therapy alone.
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