POSNOC - Clinical trial • Breast Cancer Foundation NZ

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Early Breast Cancer clinical trials for ER+

Updated: April 23, 2021

The aim of the POSNOC trial is to find out if further axillary treatment is of benefit in women with macrometastases found in one or two lymph nodes.

Standard treatment for early breast cancer that has spread to one or two lymph nodes includes further treatment to the armpit. Research suggests that it may be possible to avoid the removal of all axillary nodes. Patients may be spared the potential side effects of having extra treatment to the axilla including lymphoedema.

The study will compare adjuvant therapy alone with adjuvant therapy plus axillary treatment (axillary node clearance (ANC) or axillary radiotherapy (ART)).

Participants will be followed up for five years.

All participants will receive adjuvant systemic therapy (chemotherapy and/or endocrine therapy). All participants may receive breast/chest wall radiotherapy. Axillary and supraclavicular fossa radiotherapy is not allowed when randomised to adjuvant therapy alone.

Full trial information

New Zealand

Auckland City Hospital
Palmerston North Hospital
Rotorua Hospital
Waikato Hospital


Auckland City Hospital: Haewon Park
Palmerston North Hospital: Rebecca Va'ai-Wells
Rotorua Hospital: Jenni Scarlet
Waikato Hospital: Jenni Scarlet


Royal Adelaide Hospital, Adelaide
Mater Adult Hospital, Brisbane
Coffs Harbour Health Campus, Coffs Harbour
The Breast & Endocrine Centre, Lake Macquarie
Genesis Cancer Care, Lake Macquarie
Box Hill Hospital, Melbourne
Maroondah Hospital, Melbourne
Monash Cancer Centre (MMC Moorabbin), Melbourne
The Royal Melbourne Hospital, Melbourne
The Royal Women’s Hospital, Melbourne
Sunshine Hospital, Melbourne
Fiona Stanley Hospital, Perth
Sir Charles Gairdner Hospital, Perth
St John of God Subiaco Hospital, Perth
Bankstown-Lidcombe Hospital, Sydney
Mater Hospital, Sydney
Westmead Hospital, Sydney
Riverina Cancer Care Centre, Wagga Wagga

If you think you might be a candidate for this trial, use the contact details supplied, or talk to your doctor.

Want to access a trial that's not in your area? It's not always possible, but if you're interested, email us at intouch@bcf.org.nz

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Are we out of date? If you have updated or new information about a trial, we’d be grateful if you’d share it with us – email your update to intouch@bcf.org.nz

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