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This study will look at if Vagifem Low tablets can treat symptoms like vaginal itching, pain and irritation for women taking aromatase inhibitors after finishing active breast cancer treatment. We hope this study will further medical knowledge and may improve treatment of genitourinary symptoms for women in the future.
Who is it for?
You may be eligible to join this study if you are female, aged 18 and above, have early breast cancer (stage I-III), on an aromatase inhibitor for at least three months and are experiencing genitourinary symptoms.
All participants in this study receive estradiol vaginal pessaries (Vagifem Low) for 12 weeks (daily application for the first 14 days, then twice a week application for the next ten weeks).
Feasibility/adherence to treatment will be assessed using a participant diary. This study will also assess symptom response, quality of life and sexual function using questionnaires and the effect of this treatment on blood levels of oestrogen.
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